Delivering Methylated Vitamins That Actually Work
At Vitamins That Work, we specialize in one thing: methylated B vitamins
Every recommendation we make is based on clinical research, ethical sourcing, and active nutrient forms
Our content is rooted in science, not hype. We review supplements through a lens of genetic compatibility, bioavailability, and transparency. Because when it comes to B vitamins, the form matters and so does your DNA.
We’re not doctors we’re researchers and affiliate marketers committed to honest reviews. From methylated B-complexes to genetic testing tools, everything we share meets strict, non-negotiable quality standards.
Always consult your healthcare provider before starting any supplement. Our content is educational, not medical advice.
Ready to find the right methylated B vitamins for your body? Start with a genetic test and discover what your body really needs.
Delivering the Right B Vitamins for Your Unique MTHFR Mutation
One-size-fits-all vitamins don’t work when your genes say otherwise. As someone who researches supplements full-time, I’ve seen how MTHFR mutations can drastically change how your body uses B vitamins—especially folate, B12, and B6. That’s why I created this guide: to connect your exact genetic combination with the right bioavailable B-complex supplement.
Every product below meets strict, non-negotiable criteria:
- Clinically studied with peer-reviewed data
- Bioavailable forms only (methylfolate, methylcobalamin, P-5-P, etc.)
- No fillers, additives, or proprietary blends
- Non-GMO, third-party tested, and ethically sourced
This isn’t a generic “top B vitamins” list—it’s a personalized matching system based on your specific MTHFR genotype combination. Whether you’re heterozygous, homozygous, or compound, I’ve linked the best methylated B complex for your needs—directly from Amazon, where you can easily check ingredients, reviews, and lab testing for yourself.
Use the chart above to find your combination and select the linked product that aligns with your methylation support needs.
Important: I’m not a doctor, and this isn’t medical advice. What I share is based on science, not sponsorship. I always recommend consulting with your practitioner before starting any new supplement.
| Genotype | Supplement | Key Features | Why It Works |
|---|---|---|---|
| C677T: CC + A1298C: AA | Pure Encapsulations B-Complex Plus | Methylfolate, Methylcobalamin, P-5-P, Hypoallergenic | Foundational support without excess methyl donors |
| C677T: CT + A1298C: AA | Jarrow Formulas B-Right | Methylfolate, Methylcobalamin, P-5-P, Choline | Balanced methylation support, mild variant |
| C677T: TT + A1298C: AA | Thorne Research Basic B Complex | Methylfolate, Methylcobalamin, P-5-P, No fillers | High support for enzyme reduction, tested formula |
| C677T: CC + A1298C: AC | Garden of Life Raw B Complex | Whole-food base, Probiotics, Methylated B vitamins | Gentle support for neurotransmitter function |
| C677T: CC + A1298C: CC | Klaire Labs B Complex Plus | Methylfolate, Methylcobalamin, Choline, Inositol | Supports neurotransmitter and detox pathways |
| C677T: CT + A1298C: AC | Pure Therapro Rx Methyl Active B | Methylfolate, Methylcobalamin, TMG, P-5-P | Comprehensive for dual mutation support |
| C677T: TT + A1298C: AC | Methylated B Complex 9-in-1 | 9-in-1, TMG, Methylfolate, Methylcobalamin | Supports high methylation and homocysteine |
| C677T: CT + A1298C: CC | Klaire Labs B Complex Plus | Methylfolate, Methylcobalamin, P-5-P, Active coenzymes | Targets neurotransmitter and detox needs |
| C677T: TT + A1298C: CC | Optimal Multivitamin by Seeking Health | Methylfolate, Methylcobalamin, TMG, P-5-P | Severe support for complex methylation |
Note: Always consult with a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or are on medication.
Methylated B Vitamins and Gene Support
Bioavailable forms of B vitamins matched to specific gene mutations based on peer-reviewed evidence.
| Methylated B Vitamin | Gene Mutations Supported | Optimal Form | Clinical Use Case | PubMed Link |
|---|---|---|---|---|
| L-Methylfolate (B9) | MTHFR (C677T, A1298C), DHFR | Quatrefolic® or Metafolin® | Bypasses MTHFR enzyme block, supports DNA methylation | Study |
| Methylcobalamin (B12) | MTR, MTRR, TCN2, FUT2 | Methylcobalamin (sublingual/injection) | Supports remethylation of homocysteine to methionine | Study |
| Pyridoxal-5-Phosphate (B6) | CBS, SHMT1 | P-5-P (active B6) | Supports transsulfuration and neurotransmitter synthesis | Study |
| Riboflavin-5-Phosphate (B2) | MTHFR, MTRR | FAD or Riboflavin-5′-Phosphate | Stabilizes MTHFR enzyme in 677TT genotype | Study |
| Betaine (TMG) | BHMT, PEMT | Trimethylglycine | Alternative methyl donor when MTHFR/MTR is impaired | Study |
Genetically Matched Methylated Vitamins for MTHFR, COMT, and More
Featured: Methylated B Complex Designed for Your Genetic Needs
If you have gene variations like MTHFR, MTRR, CBS, or COMT, your body may struggle to process standard B vitamins. That’s where Micro Ingredients Pure Methylated B Complex stands out. This formula delivers only active, methylated vitamins no synthetic forms, no fillers, just nutrients your body can use.
Formulated with L-5-MTHF, methylcobalamin, P5P, R5P, choline, and inositol, this 11-in-1 B complex is designed to bypass genetic bottlenecks and support optimal methylation. Whether you’re dealing with fatigue, poor focus, mood swings, or elevated homocysteine, this supplement targets the root causes linked to your unique genetic makeup.
- MTHFR C677T/A1298C: Supports methylation with active folate (L-5-MTHF)
- MTR/MTRR: Provides methyl B12 and methyl donors to support homocysteine recycling
- CBS: Includes P5P and choline to regulate sulfur metabolism
- COMT: Balanced methylation with niacinamide to buffer overstimulation
- PEMT/FADS1: Choline and inositol support healthy methyl donor production and detox
This formula is non-GMO, filler-free, third-party tested, and designed for real-world results not just label claims. With 240 capsules per bottle, it’s a clean, cost-effective solution for long-term genetic support.
Read the full product review to learn how this formula ranks for purity, absorption, and genetic compatibility.
Disclaimer: The information provided on this website is for educational purposes only and is not intended as medical advice. I am an independent researcher sharing peer-reviewed science and product analysis. Always consult with a licensed healthcare professional before starting any supplement or health regimen.
- Micro Ingredients offers Pure Methylated B Complex Vitamins. 11-in-1 support with fat-soluble vitamin C. A capsuled form…
- Each bottle contains 240 capsules. Offers vitamin C (ascorbyl palmitate + ascorbic acid), thiamin, riboflavin (R5P), nia…
- An advanced B complex with vitamin C, choline, and inositol promotes various health benefits that target energy, cellula…
Scientific References: Genetic Mutations and Methylated Vitamins
Impact of COMT Activity on Neurotransmitter Methylation and Mood
MTHFR (C677T, A1298C)
Folate and MTHFR Deficiency in Neurological and Psychiatric Disorders
Effect of MTHFR 677C>T on Homocysteine and Folate Status
L-methylfolate as an Adjunctive Treatment in MTHFR Variants
MTR / MTRR
Polymorphisms in MTR and MTRR and Their Influence on Homocysteine Levels
Methylcobalamin and Homocysteine Metabolism in MTR/MTRR Carriers
CBS (Cystathionine Beta-Synthase)
CBS Gene Variants and Transsulfuration Pathway Regulation
Vitamin B6 as a Cofactor for CBS in Homocysteine Clearance
COMT (Catechol-O-Methyltransferase)